Do you have asthma?

In this research study we want to learn if Dupixent® (Dupilumab) helps to control your asthma. We are particularly interested in understanding if people who have a certain genetic make-up (genotype) will respond better to this treatment.

Dupixent® (Dupilumab) is currently FDA approved in people 12 and older as an add-on treatment for uncontrolled moderate to severe asthma. It works by inhibiting the overactive signaling of two key proteins, [interleukin-4 (IL-4) and interleukin-13 (IL-13)]{:target=”blank”}, that contribute to the inflammation that may cause moderate-to-severe asthma.

We hope to learn if Dupixent® (Dupilumab) works better in certain people whose genes may make them more inclined to have difficult to control asthma. We will also study how long Dupixent® (Dupilumab) will help after the treatment is stopped.

As with any medication, there is a chance you will experience an allergic reaction to Dupixent®. The chance of an allergic reaction is very low. The most common side effect is temporary pain or discomfort where the injection was given.

We’re looking for participants 12 years and above who have asthma.

The study consists of a one-year treatment period, followed by 6 months of observation. During the 1-year treatment period, we will ask you to come in for a study visit a total of 7 times. We will show you how to self-administer the first injection and you will be asked to give yourself the medication at home every 2 weeks. Half of the participants will receive Dupixent®, the other half will be treated with placebo. We will then follow up by phone and we will ask you to come in twice for a study visit during the observation phase.

Blood will be obtained at 5 time points throughout the study. Lung function testing will be done every time you come for a study appointment.

Yes, participants will receive compensation at each visit (up to a total of $870 over the 18-month study), travel compensation, access to study doctors for breathing symptom management (including free medications, if needed).